Malignant transformation of oral leukoplakia: Systematic review and comprehensive meta-analysis.

ABSTRACT:

Objectives

To update the current evidence on the malignant transformation of oral leukoplakia (OL), including all studies published worldwide on the subject, selected with the maximum rigor regarding eligibility.

Materials and methods

MEDLINE, Embase, Web of Science and Scopus were searched for studies published before June-2024, with no lower date limit. The risk of bias was analyzed using the Joanna Briggs Institute tool for meta-analyses of proportions. We carried out meta-analyses, explored heterogeneity across subgroups and identified risk factors with potential prognostic value.

Results

Fifty-five studies (41,231 with OL) were included. The pooled malignant transformation proportion for OL was 6.64% (95% CI = 5.21-8.21). The malignant transformation did not sign

SUBMITTER: Pimenta-Barros LA 

PROVIDER: S-EPMC11808172 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature