Nonmotor Symptoms Differ Between Essential Tremor and Tremor-Dominant Parkinson's Disease.

ABSTRACT:

Background

Distinguishing between essential tremor (ET) and tremor-dominant Parkinson's disease (PD-TD) can be challenging due to overlapping motor symptoms. This study aims to investigate the differences in nonmotor symptoms (NMS) between ET and PD-TD patients to provide additional evidence for differentiating these two conditions.

Methods

This retrospective study included 1656 participants, comprising 558 PD-TD patients, 584 ET patients, and 514 controls. ET patients were assessed using the Tremor Research Group Essential Tremor Rating Assessment Scale (TETRAS), while PD-TD patients were evaluated based on the Unified Parkinson's Disease Rating Scale (UPDRS). All participants were assessed for NMS using the Nonmotor Symptoms Scale (NMSS).

Results

The composite NMSS

SUBMITTER: Li M 

PROVIDER: S-EPMC11808177 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature