The Interaction Between Cognitive Abilities and White Matter Hyperintensity Phenotypes: A Novel Perspective on Bidirectional Causality.

ABSTRACT:

Purpose

This study utilizes bidirectional Mendelian randomization (MR) to examine the causal relationships between white matter hyperintensity (WMH) phenotypes-namely, WMH volume, fractional anisotropy (FA), and mean diffusivity (MD)-and cognitive abilities, including cognitive performance, intelligence, and overall cognitive function.

Methods

This study leverages genetic variation data from genome-wide association study (GWAS) datasets and employs a bidirectional two-sample MR analysis. The analysis incorporates MR Egger, weighted median, weighted mode, and inverse variance weighted (IVW) methods to assess the bidirectional causal relationship between cognitive abilities and WMH volume, FA, and MD.

Results

This study employed MR to explore the causal relationships be

SUBMITTER: Ren X 

PROVIDER: S-EPMC11808190 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature