Low-Frequency Stimulation at the Ventromedial Hypothalamus Exhibits Broad-Spectrum Efficacy Across Models of Epilepsy.

ABSTRACT:

Aims

The limited efficacy and very restricted antiseizure range of current deep brain stimulation (DBS) targets highlight the need to find an optimal target for managing various seizure types. Here, we aimed to investigate the efficacy of DBS on the ventromedial hypothalamus (VMH) in the different types of experimental epileptic seizures.

Methods

The efficacy of DBS was examined in various epileptic seizure models, and the potential mechanisms were investigated by using in vivo calcium signal recording and optogenetics.

Results

The c-fos expression was significantly increased in the glutamatergic neurons of VMH (VMH^glu) following seizures. Then, 1-Hz low-frequency stimulation (LFS) at the VMH successfully attenuated the seizure severities across models of e

SUBMITTER: Zou S 

PROVIDER: S-EPMC11808192 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature