Genome-wide changes of protein translation levels for cell and organelle proliferation in a simple unicellular alga.

ABSTRACT: Cell proliferation is a fundamental characteristic of organisms, driven by the holistic functions of multiple proteins encoded in the genome. However, the individual contributions of thousands of genes and the millions of protein molecules they express to cell proliferation are still not fully understood, even in simple eukaryotes. Here, we present a genome-wide translation map of cells during proliferation in the unicellular alga Cyanidioschyzon merolae, based on the sequencing of ribosome-protected messenger RNA fragments. Ribosome profiling has revealed both qualitative and quantitative changes in protein translation for each gene during cell division, driven by the large-scale reallocation of ribosomes. Comparisons of ribosome footprints from non-dividing and dividing cells allowed the

SUBMITTER: Mogi Y 

PROVIDER: S-EPMC11808204 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature