Klf10 Regulates the Emergence of Glial Phenotypes During Hypothalamic Development.

ABSTRACT: Glial cells play a pivotal role in the Central Nervous System (CNS), constituting most brain cells. Gliogenesis, crucial in CNS development, occurs after neurogenesis. In the hypothalamus, glial progenitors first generate oligodendrocytes and later astrocytes. However, the precise molecular mechanisms governing the emergence of glial lineages in the developing hypothalamus remain incompletely understood. This study reveals the pivotal role of the transcription factor KLF10 in regulating the emergence of both astrocyte and oligodendrocyte lineages during embryonic hypothalamic development. Through transcriptomic and bioinformatic analyses, we identified novel KLF10 putative target genes, which play important roles in the differentiation of neurons, astrocytes, and oligodendrocytes. Notably,

SUBMITTER: Garduno-Tamayo NA 

PROVIDER: S-EPMC11808290 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature