The imprinted Igf2-Igf2r axis is critical for exosome biogenesis during the early development of bovine placenta.

ABSTRACT: Insulin-like growth factor 2 (IGF2) is essential for cell growth and differentiation and functions through the IGF2 receptor (IGF2R) to regulate embryonic and placental development. Exosomes that are synthesized and released from cells and play important roles in embryogenesis and placental development rely on the IGF2R for sorting and transport. However, the role of the imprinted Igf2-Igr2r axis and exosomes in the co-regulation of early placental development remains unknown. Cotyledon villi were collected from bovine placentas at different gestational ages, and the localization and expression of IGF2, IGF2R, and exosomal marker proteins were detected. Furthermore, the expression of exosomal marker factors was detected after the expression of IGF2R or IGF2 was inhibited through RNA interf

SUBMITTER: Zheng K 

PROVIDER: S-EPMC11808309 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature