Exploring hepatic hormone actions using a compilation of gene expression profiles.

ABSTRACT:

Background

Microarray analysis is attractive within the field of endocrine research because regulation of gene expression is a key mechanism whereby hormones exert their actions. Knowledge discovery and testing of hypothesis based on information-rich expression profiles promise to accelerate discovery of physiologically relevant hormonal mechanisms of action. However, most studies so-far concentrate on the analysis of actions of single hormones and few examples exist that attempt to use compilation of different hormone-regulated expression profiles to gain insight into how hormone act to regulate tissue physiology. This report illustrates how a meta-analysis of multiple transcript profiles obtained from a single tissue, the liver, can be used to evaluate relevant hypothesis and dis

SUBMITTER: Stahlberg N 

PROVIDER: S-EPMC1180834 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature