Photoredox-catalyzed deoxygenative radical transformation of alcohols to sulfinamides.

ABSTRACT: Sulfinamides play a crucial role in organic synthesis and pharmaceuticals. In this study, we introduce a highly effective method for the deoxygenative radical addition to N-tritylsulfinylamine, which produces sulfinamides via photoredox catalysis. This method is compatible with a diverse array of functional groups and the resulting sulfonamides were achieved in moderate to high yields. Furthermore, the synthetic applications to access various sulfur(vi)-centered functional groups highlight the practicality of this approach.

SUBMITTER: Zhu X 

PROVIDER: S-EPMC11808478 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature