Propofol, Triglycerides, and Acute Pancreatitis: A Multicenter Epidemiologic Analysis.

ABSTRACT: Rationale: Propofol is one of the first-line sedative-hypnotic agents for critically ill adults requiring mechanical ventilation. Although propofol can elevate triglyceride levels, and the latter is a risk factor for pancreatitis, the association between propofol and acute pancreatitis is unclear. Objectives: We sought to determine the clinical impact and potential associations between propofol infusion, hypertriglyceridemia, and acute pancreatitis. Methods: This is an observational multicenter study of adults (⩾18 yr old) who were admitted to an intensive care unit, who required mechanical ventilation and received continuous propofol infusion for at least 24 hours. The primary outcomes were the frequency of hypertriglyceridemia (>400 mg/dl) and acute pancreatitis. Fur

SUBMITTER: Heybati K 

PROVIDER: S-EPMC11808550 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature