Diagnosis of TP53-mutated myeloid disease by the ICC and WHO fifth edition classifications.

ABSTRACT:

Abstract

The International Consensus (ICC) and World Health Organization fifth edition (WHO5) classifications introduced new, but differing, categories of myeloid disease defined by TP53 mutations. We reviewed a cohort of 188 cases of TP53-mutated myeloid disease to determine how diagnoses and outcomes differ between the 2 classifications. Overall, 120 (64%) cases were classified differently by the ICC and WHO5, including 24 of 80 (30%) cases with <20% blasts. These cases were discrepantly categorized primarily because of inclusion of complex karyotype (CK) as a surrogate for biallelic TP53 inactivation only in the ICC. However, there were no significant differences in clinicopathologic characteristics or overall survival between cases categorized as TP53-mutated disease by both cl

SUBMITTER: Hart SA 

PROVIDER: S-EPMC11808619 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature