Comparative analysis of bio-based plasticizers: biocompatibility, plasticizing mechanisms, and molecular dynamics insights.

ABSTRACT: The advantages of bio-based plasticizers and the differences in their biotoxicity and plasticizing mechanisms compared to phthalate plasticizers have rarely been systematically investigated. Epoxidized soybean oil (ESO), triphenyl phosphate (TCP), and acetyl tributyl citrate (ATBC) were specifically chosen for a rigorous comparative analysis with diocty phthalate (DOP), employing a blend of toxicological studies, characterization methodologies and molecular dynamics (MD) simulations. Based on the blood routine indicators and liver tissue pathology analysis in SD rats, the biocompatibility ranking is as follows: ESO > ATBC > TCP > DOP. When the plasticizer content is 40 wt%, ATBC/PVC and ESO/PVC exhibit superior elongation at break compared to DOP/PVC. MD results indicate that ATBC, ESO, TC

SUBMITTER: Gao L 

PROVIDER: S-EPMC11808658 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature