Feasibility study: Varespladib protects CD-1 mice from lethal doses of whole bee (<i>Apis mellifera</i>) venom.

ABSTRACT: Swarming Hymenoptera attacks can deliver high cumulative doses of venom resulting in death and life-threatening or chronically disabling injuries. Varespladib, a potent inhibitor of snake venom secretory PLA2 (sPLA2), is a relatively weak inhibitor of whole bee venom sPLA2 in vitro (pico-to low nanomolar for snake venom compared to μ M for Apis millera). Animal studies of varespladib against wasp (Vespa mandarinia) venom have shown promise against both nephropathy and coagulopathy, major markers of severe systemic toxicity distinct from hypersensitivity such as anaphylactoid and anaphylaxis reactions. We conducted a simple pilot study to evaluate if varespladib could feasibly decrease mortality against lethal doses of honeybee (Apis mellifera) venom in a murine

SUBMITTER: Hearth J 

PROVIDER: S-EPMC11808668 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature