The frequency of mutations in the <i>pen</i>A, <i>mtr</i>R, <i>gyr</i>A and <i>par</i>C genes of <i>Neisseria gonorrhoeae</i>, the presence of <i>tet</i>M gene and antibiotic resistance/susceptibility: a systematic review and meta-analyses.

ABSTRACT: Gonorrhoea is currently one of the most important sexually transmitted infections (STIs) due to the increasing spread of multidrug-resistant strains of N. gonorrhoeae. The aim of this study was to analyse the association between resistance or decreased susceptibility to antibiotics in N. gonorrhoeae and the presence of mutations in the penA, mtrR, gyrA and parC genes, and the presence of tetM gene. We conducted a systematic review according to the PRISMA guidelines. We selected 19 studies for the penA gene, 23 for gyrA and parC, 18 for mtrR and 12 for tetM using the Science Direct and PubMed databases. Meta-analyses of isolates resistant to penicillin, cefixime and ceftriaxone showed that more than 50% of isolates

SUBMITTER: Mendes AC 

PROVIDER: S-EPMC11808683 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature