Investigation into Drug-Induced Liver Damage Using Multimodal Mass Spectrometry Imaging.

ABSTRACT: Drug toxicity during the development of candidate pharmaceuticals is the leading cause of discontinuation in preclinical drug discovery and development. Traditionally, the cause of the toxicity is often determined by histological examination, clinical pathology, and the detection of drugs and/or metabolites by liquid chromatography-mass spectrometry (LC-MS). While these techniques individually provide information on the pathological effects of the drug and the detection of metabolites, they cannot provide specific molecular spatial information without additional experiments. Matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) is a powerful, label-free technique for the simultaneous detection of pharmaceuticals, metabolites, and endogenous chemical species in t

SUBMITTER: Flinders B 

PROVIDER: S-EPMC11808762 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature