Antifungal and Antiparasitic Activities of Metallocene-Containing Fluconazole Derivatives.

ABSTRACT: The search for new anti-infectives based on metal complexes is gaining momentum. Among the different options taken by researchers, the one involving the use of organometallic complexes is probably the most successful one with a compound, namely, ferroquine, already in clinical trials against malaria. In this study, we describe the preparation and in-depth characterization of 10 new (organometallic) derivatives of the approved antifungal drug fluconazole. Our rationale is that the sterol 14α-demethylase is an enzyme part of the ergosterol biosynthesis route in Trypanosoma and is similar to the one in pathogenic fungi. To demonstrate our postulate, docking experiments to assess the binding of our compounds with the enzyme were also performed. Our compounds were then tested on a range

SUBMITTER: Lin Y 

PROVIDER: S-EPMC11808820 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature