Diagnostic alignment to optimize inter-rater reliability among lung transplant pathologists.

ABSTRACT:

Background

Poor agreement among lung transplant (LTx) pathologists has been reported in the assessment of rejection. In addition to acute rejection (AR) and lymphocytic bronchiolitis (LB), acute lung injury (ALI) and organizing pneumonia (OP) were recently identified as histopathologic risk factors for chronic lung allograft dysfunction (CLAD). Therefore, maximizing inter-rater reliability (IRR) for identifying these histopathologic risk factors is important to guide individual patient care and to support incorporating them in inclusion criteria for clinical trials in lung transplantation.

Methods

Nine pathologists across 8 North American LTx centers were surveyed for practices in the assessment of LTx transbronchial biopsies. We conducted 7 diagnostic alignment sessions wit

SUBMITTER: Pavlisko EN 

PROVIDER: S-EPMC11808823 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature