A framework for modelling whole-lung and regional transfer factor of the lung for carbon monoxide using hyperpolarised xenon-129 lung magnetic resonance imaging.

ABSTRACT:

Background

Pulmonary gas exchange is assessed by the transfer factor of the lungs (T _L) for carbon monoxide (T _LCO), and can also be measured with inhaled xenon-129 (¹²⁹Xe) magnetic resonance imaging (MRI). A model has been proposed to estimate T _L from ¹²⁹Xe MRI metrics, but this approach has not been fully validated and does not utilise the spatial information provided by three-dimensional ¹²⁹Xe MRI.

Methods

Three models for predicting T _L from ¹²⁹Xe MRI metrics were compared: 1) a previously-published physiology-based model, 2) multivariable linear regression and 3) random forest regression. Models were trained on data from 150 patients with asthma and/or CO

SUBMITTER: Pilgrim-Morris JH 

PROVIDER: S-EPMC11808933 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature