Pertussis infection in critically ill infants: meta-analysis and validation of a mortality score.

ABSTRACT:

Background

Despite widespread vaccination programs, pertussis continues circulating within populations and remains a life-threatening infection in infants. While several mortality risk factors have been described, a comprehensive synthesis is lacking. We conducted a meta-analysis of studies investigating mortality risk factors in Pertussis infections and validated those factors in a large cohort.

Methods

Observational studies published in English were systematically searched in PubMed, EMBASE, and LiSSa databases from 01/2000 to 06/2024. The search yielded 816 unique citations. The primary outcome was mortality before discharge from the Pediatric Intensive Care Unit (PICU). Two independent reviewers assessed the risk of bias and extracted data. A REML-random effect model was

SUBMITTER: Cousin VL 

PROVIDER: S-EPMC11808955 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature