Tension-sensitive HOX gene expression in fibroblasts for differential scar formation.

ABSTRACT:

Background

Scar formation is a common end-point of the wound healing process, but its mechanisms, particularly in relation to abnormal scars such as hypertrophic scars and keloids, remain not fully understood. This study unveils a novel mechanistic insight into scar formation by examining the differential expression of Homeobox (HOX) genes in response to mechanical forces in fibroblasts derived from normal skin, hypertrophic scars, and keloids.

Methods

We isolated fibroblasts from different scar types and conducted RNA sequencing (RNA-Seq) to identify differential gene expression patterns among the fibroblasts. Computational modeling provided insight into tension alterations following injury, and these findings were complemented by in vitro experiments where fibroblasts were

SUBMITTER: Kang M 

PROVIDER: S-EPMC11808978 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature