Oral microbiota shifts following tooth loss affect gut health.

ABSTRACT:

Background

Tooth loss not only impairs oral function but also affects gut health by altering the host microbiota. Understanding the oral-gut axis can provide insights into systemic health implications following tooth loss.

Methods

Using an animal model, we extracted the molars of C57 mice. Saliva and fecal samples were collected for 16S rRNA and metagenomic sequencing to analyze changes in the oral and gut microbiota. Pearson correlation analysis assessed the relationship between altered microbial communities.

Results

The study found a significant reduction in oral microbiota diversity following tooth loss, with increased Proteobacteria and decreased Muribacter. Gut microbiota showed increased Firmicutes and decreased Bacteroidota. Correlations between oral and gut mi

SUBMITTER: Dong L 

PROVIDER: S-EPMC11808984 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature