Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have uncovered the genetic basis behind many diseases and conditions. However, most of these genetic loci affect regulatory regions, making the interpretation challenging. Chromatin conformation has a fundamental role in gene regulation and is frequently used to associate potential target genes to regulatory regions. However, previous studies mostly used small sample sizes and immortalized cell lines instead of primary cells.

Results

Here we present the most extensive dataset of chromatin conformation with matching gene expression and chromatin accessibility from primary CD4⁺ and CD8⁺ T cells to date, isolated from psoriatic arthritis patients and healthy controls. We generated 108 Hi-C libraries (49 bil

SUBMITTER: Shi C 

PROVIDER: S-EPMC11808986 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature