Association between cytokine and increased risk of death in ART- naive and ART-non-adherence patients hospitalized with advanced HIV disease.

ABSTRACT:

Background

Despite progress in healthcare for people living with HIV/AIDS (PLWHA), many still present with advanced HIV, thus increasing their risk of death. Late initiation of treatment and poor adherence to antiretroviral therapy (ART) are key contributing factors. This study aimed to evaluate cytokines as mortality predictors among hospitalized PLWHA. It assessed the risk of death between ART-naïve and ART-non-adherent PLWHA with advanced HIV and quantified immunological markers in post-mortem samples to determine the influence of irregular ART use.

Methods

A longitudinal observational study was conducted at the Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD) in Manaus, Brazil, with 111 participants recruited between 2018 and 2019. Clinical and labora

SUBMITTER: Chaves YO 

PROVIDER: S-EPMC11808995 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature