Global burden of colorectal cancer attributable to metabolic risks from 1990 to 2021, with predictions to 2046.

ABSTRACT:

Background

Metabolic risks are significant factors associated with colorectal cancer. This study aimed to assess global, regional and national burden for CRC attributable to metabolic risks from 1990 to 2021 and to predict mortality by 2046.

Methods

Data from the Global Burden of Disease Study 2021 were used to quantify deaths, disability-adjusted life years (DALYs), and age-standardized rates of CRC due to metabolic risk factors, disaggregated by sex, age, region, country/territory, and sociodemographic index (SDI). The average annual percentage change (AAPC) was used to analyze temporal trends from 1990 to 2021. Metabolic risks include high fasting plasma glucose (FPG) and high body mass index (BMI). Future mortality trends up to 2046 were forecast using age-period-cohort

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11809015 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature