CDCA genes as prognostic and therapeutic targets in Colon adenocarcinoma.

ABSTRACT:

Objectives

The study investigates the role of Cell Division Cycle Associated (CDCA) genes in colorectal cancer (COAD) by analyzing their differential expression, epigenetic alterations, prognostic significance, and functional associations.

Methodology

This study employed a detailed in silico and in vitro experiments-based methodology.

Results

RT-qPCR assays reveal significantly elevated mRNA levels of CDCA2, CDCA3, CDCA4, CDCA5, CDCA7, and CDCA8 genes in COAD cell lines compared to controls. Bisulfite sequencing indicates reduced promoter methylation of CDCA gene promoters in COAD cell lines, suggesting an epigenetic regulatory mechanism. Analysis of large TCGA datasets confirms increased CDCA gene expression in COAD tissues. Survival analysis using cSurvival database

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC11809055 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature