Bioinformatics insights into ACSL1 and ACSL5: prognostic and immune roles in low-grade glioma.

ABSTRACT:

Background

Fatty acid metabolism disruptions affect low-grade gliomas (LGGs), with glioma cells depending on fatty acids for survival. Targeting fatty acid oxidation through the acyl-coenzyme A synthetase long-chain (ACSL) family could alleviate glioma growth and improve prognosis management. However, the integration of ACSLs for analyzing their relationship with LGGs remains unexplored.

Methods

We collected RNA expression data of ACSLs for LGGs from TCGA, GTEx, CGGA, and GEO datasets and validated the prognostic significance of gene expression in 37 glioma samples. DNA methylation data from UCSC Xena and promoter methylation levels via MEXPRESS were analyzed. Functional enrichments of co-expressed ACSLs genes were conducted using Gene Ontology, Kyoto Encyclopedia of Genes a

SUBMITTER: Zhang C 

PROVIDER: S-EPMC11809057 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature