Challenges in measuring nanoparticles and microparticles by single particle ICP-QMS and ICP-TOFMS: size-dependent transport efficiency and limited linear dynamic range.

ABSTRACT: While spICP-MS has been used mainly to measure nanoparticles, it can also be used to measure microparticles. The transport efficiency of nanoparticles is typically independent of their size. However, the transport efficiency of microparticles can be particle size (mass) dependent as well as being dependent on the sample uptake rate and sample introduction system used. To measure both nanoparticles and microparticles a very large linear dynamic range (where signal intensity is linearly proportional to the measured analyte(s) mass within a very short measurement time (∼300 to 500 µs, the width of signals produced by an individual particle)) is needed. Deviations from linearity could occur due to incomplete particle vaporization or from signals that are beyond the instrument's ion detection s

SUBMITTER: Lomax-Vogt M 

PROVIDER: S-EPMC11809140 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature