Single-cell sequencing of peripheral blood mononuclear cells reveals immune landscape of monkeypox patients with HIV.

ABSTRACT: The monkeypox (MPXV) outbreak in 2022 is more prevalent among individuals with human immunodeficiency virus (HIV). While it is plausible that HIV-induced immunosuppression could result in a more severe progression, the exact mechanisms remain undetermined. To better understand the immunopathology of MPXV in patients with and without HIV infection, we employed single-cell RNA sequencing (scRNA-seq) to analyse peripheral blood mononuclear cells (PBMCs) from six patients hospitalized for MPXV, three of whom had HIV infection (HIV antibody positive and HIV RNA level below the detection limit), and three patients only infected with MPXV (HIV-). We map the peripheral immune response in both the acute phase and the recovery period, showing the reconfiguration of peripheral immune cell phenotypes

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11809181 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature