Waist-to-hip ratio better reflect beta-cell function and predicts diabetes risk in adult with overweight or obesity.

ABSTRACT:

Objective

Controversy remains as to which obesity measures better predict type 2 diabetes (T2D) risk in overweight or obese individuals. The objective of this study is to determine which commonly used obesity measures better reflect beta cell function and predict T2D risk in participants with overweight or obesity and to validate the findings using prospective cohort data.

Patients and methods

Cross-sectional data from the Obesity Clinic of the Xiangya Hospital of the Central South University and prospective cohort from UK Biobank. BMI, waist circumference (WC), waist-to-hip ratio (WHpR), and waist-to-height ratio (WHtR) were measured. Primary outcomes included beta cell function indices in the cross-sectional study and the occurrence of diabetes obtained from UK Biobank dat

SUBMITTER: Liu N 

PROVIDER: S-EPMC11809193 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature