Structural and functional correlates of olfactory reward processing in behavioral variant frontotemporal dementia.

ABSTRACT: The behavioral variant of frontotemporal dementia (bvFTD) includes symptoms that reflect altered pursuit of rewards, including food, alcohol, and money. Little is known, however, about how these reward changes relate to atrophy and functional connectivity within reward-related regions. The goal of this study was to examine the structural and functional correlates of valence perception for olfactory rewards in 24 patients with bvFTD. Regression analysis of resting-state brain functional connectivity indicated that more positive valence ratings of olfactory stimuli were predicted by ventral pallidum connectivity to other reward circuit regions, particularly functional connectivity between ventral pallidum and bilateral anterior cingulate cortex/ventromedial prefrontal cortex. Structural anal

SUBMITTER: Sokolowski A 

PROVIDER: S-EPMC11809299 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature