Nonessential kinetochore proteins contribute to meiotic chromosome condensation through polo-like kinase.

ABSTRACT: Chromosome condensation plays a pivotal role during faithful chromosome segregation, hence, understanding the factors that drive condensation is crucial to get mechanistic insight into chromosome segregation. Previously, we showed that in budding yeast, the absence of the nonessential kinetochore proteins affects chromatin-condensin association in meiosis but not in mitosis. A differential organization of the kinetochores, that we and others observed earlier during mitosis and meiosis may contribute to the meiotic-specific role. Here, with our in-depth investigation using in vivo chromosome condensation assays in cells lacking a nonessential kinetochore protein, Ctf19, we establish that these proteins have roles in achieving a higher meiotic condensation without influencing much of the mit

SUBMITTER: Trakroo D 

PROVIDER: S-EPMC11809314 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature