Wearable Temperature Sensor Enhanced Volatilomics Technique for Swift and Convenient Detection of Latrogenic Botulism.

ABSTRACT: Accurately assessing potential side effects following botulinum neurotoxin (BoNT) injection remains a formidable challenge. To address this issue, an innovative approach is developed that combines a wearable temperature sensor with a sophisticated volatilomics technique, aimed at facilitating the rapid and convenient prediction of potential physical discomfort related to latrogenic botulism. The investigation identifies five volatile organic compounds (VOCs)-acetone, styrene, ethanol, 2-pentanone, and n-butano-as promising markers indicative of BoNT poisoning. Specifically, a handheld breath analyzer, featuring a yttrium stabilized zirconia (YSZ)-based gas sensor array, alongside a wearable temperature sensor integrated with a bio-compatible methacrylated gelatin (GelMA) sensing film, are

SUBMITTER: Li X 

PROVIDER: S-EPMC11809335 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature