Ca²⁺- and cGAMP-Contained Semiconducting Polymer Nanomessengers for Radiodynamic-Activated Calcium Overload and Immunotherapy.

ABSTRACT: Various second messengers exert some vital actions in biological systems, including cancer therapy, but the therapeutic efficacy is often need to be improved. A semiconducting polymer nanomessenger (TCa/SPN/a) consisting of two second messengers, calcium ion (Ca²⁺) and cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) for metastatic breast cancer therapy, is reported here. Such a TCa/SPN/a is constructed to exhibit X-ray response for the activatable delivery of mitochondria-targeting Ca compound and cGAMP as stimulator of interferon genes (STING) agonist. With X-ray irradiation, TCa/SPN/a could generate singlet oxygen (¹O₂) via radiodynamic effect for ablating solid tumors and improving the tumor immunogenicity by inducing immunogenic cell deat

SUBMITTER: Cheng D 

PROVIDER: S-EPMC11809400 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature