Number of calcified aortic valve leaflets: natural history and prognostic value in patients undergoing haemodialysis.

ABSTRACT:

Aims

Aortic valve calcification in aortic sclerosis, a precursor of aortic stenosis (AS), is not always present in all three leaflets; how calcification develops in each leaflet is unknown. We aimed to investigate the natural history of calcification development in each aortic valve leaflet and the prognostic value of the number of calcified leaflets.

Methods and results

In a retrospective multicentre cohort study of patients undergoing haemodialysis without AS, we observed calcification development in each aortic valve leaflet using echocardiography. We investigated the association between the number of calcified leaflets and AS development and mortality using time-to-event analysis. Among the 1507 patients (mean age, 66 years; 66% male) included in the longitudinal echocar

SUBMITTER: Kurasawa S 

PROVIDER: S-EPMC11809437 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature