Macroscale connectome topographical structure reveals the biomechanisms of brain dysfunction in Alzheimer's disease.

ABSTRACT: The intricate spatial configurations of brain networks offer essential insights into understanding the specific patterns of brain abnormalities and the underlying biological mechanisms associated with Alzheimer's disease (AD), normal aging, and other neurodegenerative disorders. This study investigated alterations in the topographical structure of the brain related to aging and neurodegenerative diseases by analyzing brain gradients derived from structural MRI data across multiple cohorts (n = 7323). The analysis identified distinct gradient patterns in AD, aging, and other neurodegenerative conditions. Gene enrichment analysis indicated that inorganic ion transmembrane transport was the most significant term in normal aging, while chemical synaptic transmission is a common enrichme

SUBMITTER: Zhao K 

PROVIDER: S-EPMC11809497 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature