Intermediate vs. High Oxygen Saturation Targets in Preterm Infants: A National Cohort Study.

ABSTRACT:

Introduction

Optimal oxygen saturation targets remain unknown for extremely preterm infants.

Methods

Cohort analysis of eligible preterm infants born <29 weeks' gestation admitted between 2011 and 2018 to centers submitting data to the Canadian Neonatal Network (CNN) database. Site questionnaires to determine saturation targets, alarm settings, and date of change, allowed assignation of centers to intermediate (88-93%) or high (90-95%) saturation targets. A 6-month washout period was applied to sites which switched targets during the study period. Our primary outcome was survival free of major morbidity. Secondary outcomes were death, necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), treated retinopathy of prematurity, and evidence of brain injury during adm

SUBMITTER: Taylor RS 

PROVIDER: S-EPMC11809520 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature