Prognostic value of human papilloma virus (HPV) status and programmed cell death ligand 1 (PD-L1) status in oral tongue cancer.

ABSTRACT:

Introduction

Despite advances in diagnostics and therapy, the 5-year mortality rate of oral squamous cell cancer (OSCC) remains at about 50%. Prognostic molecular biomarkers are not yet approved for clinical application, mainly due to conflicting results. The aim of our study was to determine the programmed cell death ligand 1 (PD-L1) status in oral tongue squamous cell carcinoma and their influence on patients' outcomes.

Material and methods

Primary tumours were collected from 44 patients who underwent tumour surgical resection for primary OSCC from 2018 to 2022. Additionally demographic and clinical data were gathered.

Results

Final analysis included patients with a mean age of 61 years (range 26-90), mostly males (n = 30, 68%). About half of the patients wer

SUBMITTER: Szewczyk M 

PROVIDER: S-EPMC11809567 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature