Typical and disrupted small-world architecture and regional communication in full-term and preterm infants.

ABSTRACT: Understanding the emergence of complex cognition in the neonate is one of the great frontiers of cognitive neuroscience. In the adult brain, small-world organization enables efficient information segregation and integration and dynamic adaptability to cognitive demands. It remains unknown, however, when functional small-world architecture emerges in development, whether it is present by birth and how prematurity affects it. We leveraged the world's largest fMRI neonatal dataset-Developing Human Connectome Project-to include full-term neonates (n = 278), and preterm neonates scanned at term-equivalent age (TEA; n = 72), or before TEA (n = 70), and the Human Connectome Project for a reference adult group (n = 176). Although different from adults', the small-world

SUBMITTER: Hu H 

PROVIDER: S-EPMC11809590 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature