Role of LIPIN 1 in regulating metabolic homeostasis in the retinal pigment epithelium.

ABSTRACT: Dysregulated lipid metabolism, characterized by the accumulation of lipid deposits on Bruch's membrane and in drusen, is considered a key pathogenic event in age-related macular degeneration (AMD). The imbalance of lipid production, usage, and transport in local tissues, particularly in the retinal pigment epithelium (RPE), is increasingly recognized as crucial in AMD development. However, the molecular mechanisms governing lipid metabolism in the RPE remain elusive. LIPIN1, a multifunctional protein acting as both a modulator of transcription factors and a phosphatidate phosphatase (PAP1), is known to play important regulatory roles in lipid metabolism and related biological functions, such as inflammatory responses. While deficits in LIPIN1 have been linked to multiple diseases, its spec

SUBMITTER: Usoltseva AS 

PROVIDER: S-EPMC11809763 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature