RSero: A user-friendly R package to reconstruct pathogen circulation history from seroprevalence studies.

ABSTRACT: Population-based serological surveys are a key tool in epidemiology to characterize the level of population immunity and reconstruct the past circulation of pathogens. A variety of serocatalytic models have been developed to estimate the force of infection (FOI) (i.e., the rate at which susceptible individuals become infected) from age-stratified seroprevalence data. However, few tool currently exists to easily implement, combine, and compare these models. Here, we introduce an R package, Rsero, that implements a series of serocatalytic models and estimates the FOI from age-stratified seroprevalence data using Bayesian methods. The package also contains a series of features to perform model comparison and visualise model fit. We introduce new serocatalytic models of successive outbreaks an

SUBMITTER: Hoze N 

PROVIDER: S-EPMC11809794 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature