Explore the possible influence of Sjogren's syndrome on thyroid cancer: A literature data mining and meta-analysis.

ABSTRACT:

Objectives

To explore the potential influence of Sjogren's syndrome (SS) on thyroid cancer (TC).

Methods

First, a literature data mining (LDM) approach was used to reconstruct functional pathways connecting SS and TC. A meta-analysis was then performed to examine the expression changes of genes mediated by SS using 16 TC case/control expression datasets, with results validated through the TCGA/GTEx dataset. Finally, gene set enrichment analysis (GSEA) and survival analysis using GEPIA2 were conducted on the significant genes.

Results

Our findings indicate that SS may increase the risk of TC by activating 14 TC promoters (PDCD1, NTRK1, LGALS3, CD274, FOXP3, BCL2, CYP1A1, HMGB1, TGFB1, CCL2, PLA2G7, TFF3, LCN2, and CLDN1) and suppressing three TC inhibitors (MIR145, MIR

SUBMITTER: Kong F 

PROVIDER: S-EPMC11809879 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature