Sex-dependent niche responses modulate steady-state and regenerative hematopoiesis.

ABSTRACT: Hematopoietic stem cells (HSCs) adapt to organismal blood production needs by balancing self-renewal and differentiation, adjusting to physiological demands and external stimuli. Although sex differences have been implicated in differential hematopoietic function in males versus females, the mediators responsible for these effects require further study. Here, we characterized hematopoiesis at a steady state and during regeneration following hematopoietic stem cell transplantation (HST). RNA sequencing of lineage(-) bone marrow cells from C57/Bl6 mice revealed a broad transcriptional similarity between the sexes. However, we identified distinct sex differences in key biological pathways, with female cells showing reduced expression of signatures involved in inflammation and enrichment of ge

SUBMITTER: Chaudhary R 

PROVIDER: S-EPMC11810041 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature