Comprehensive analysis of LMNB2 in pan-cancer and identification of its biological role in sarcoma.

ABSTRACT:

Backgrounds

Sarcoma (SARC) is a mesenchymal tumor which often responds poorly to systemic therapy. It is therefore important to look for possible biological markers that could tell the prognosis and the progression of SARC.

Methods

A combined evaluation of the Cancer Genome Atlas (TCGA) and genotypic tissue expression (GTEx) portal was used to analyzeLMNB2 expression level in different types of cancer. Kaplan-Meier survival analysis was performed to examine LMNB2 predictive value in over-all survival rate and disease-free survival rate. The association among LMNB2 expression level and immune cell infiltration, microsatellite instability (MSI) and tumor mutational burden (TMB) were analyzed. GO and KEGG enrichment analysis were performed to predicate LMNB2 biological function

SUBMITTER: Guo Y 

PROVIDER: S-EPMC11810055 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature