Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis.

ABSTRACT: Proliferating animal cells maintain a stable size distribution over generations despite fluctuations in cell growth and division size. Previously, we showed that cell size control involves both cell size checkpoints, which delay cell cycle progression in small cells, and size-dependent regulation of mass accumulation rates (Ginzberg et al., 2018). While we previously identified the p38 MAPK pathway as a key regulator of the mammalian cell size checkpoint (Liu et al., 2018), the mechanism of size-dependent growth rate regulation has remained elusive. Here, we quantified global rates of protein synthesis and degradation in cells of varying sizes, both under unperturbed conditions and in response to perturbations that trigger size-dependent compensatory growth slowdown. We found that protein

SUBMITTER: Liu S 

PROVIDER: S-EPMC11810107 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature