Protective effect of the "food-microorganism-SCFAs" axis on colorectal cancer: from basic research to practical application.

ABSTRACT:

Background

Recent studies have shown that the short-chain fatty acids (SCFAs) produced by the gut microbiota play a positive role in the development of colorectal cancer (CRC).

Aims

This study aims to elucidate the "food-microorganism-SCFAs" axis and to provide guidance for prevention and intervention in CRC.

Methods

The PubMed, Embase and Cochrane databases were searched from their inceptions to August 2018, and 75 articles and 25 conference abstracts were included and analysed after identification and screening.

Results

The concentrations of SCFAs in CRC patients and individuals with a high risk of CRC were higher than those in healthy individuals. The protective mechanism of SCFAs against CRC has been described in three aspects: epigenetics, immunology and m

SUBMITTER: Shuwen H 

PROVIDER: S-EPMC11810311 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature