REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression.

ABSTRACT:

Objectives

Recent research has classified lung adenocarcinoma patients with KRAS mutation into three subtypes by co-occurring genetic events in TP53 (KP subgroup), STK11/LKB1 (KL subgroup) and CDKN2A/B inactivation plus TTF-1 low expression (KC subgroup). The aim of this study was to identify valuable biomarkers by searching the candidate molecules that contribute to lung adenocarcinoma pathogenesis, especially KC subtype.

Materials and methods

We analyzed the publicly available database and identified the candidate REG4 using the E-GEOD-31210 dataset, and then confirmed by TCGA dataset. In addition, an independent cohort of 55 clinical samples was analyzed by quantitative real-time PCR analysis. Functional studies and RNA sequencing were performed after silencing the REG4 e

SUBMITTER: Sun S 

PROVIDER: S-EPMC11810320 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature