Molecular and cellular adaptations to exercise training in skeletal muscle from cancer patients treated with chemotherapy.

ABSTRACT:

Background

A growing body of evidence suggests that exercise training has beneficial effects in cancer patients. The aim of the present study was to investigate the molecular basis underlying these beneficial effects in skeletal muscle from cancer patients.

Methods

We investigated expression of selected proteins involved in cellular processes known to orchestrate adaptation to exercise training by western blot. Skeletal muscle biopsies were sampled from ten cancer patients before and after 4-7 weeks of ongoing chemotherapy, and subsequently after 10 weeks of continued chemotherapy in combination with exercise training. Biopsies from ten healthy matched subjects served as reference.

Results

The expression of the insulin-regulated glucose transporter, GLUT4, increased d

SUBMITTER: Moller AB 

PROVIDER: S-EPMC11810380 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature