Iloprost Concentration-Dependently Attenuates Platelet Function and Apoptosis by Elevating PKA Activity.

ABSTRACT: Iloprost, a prostacyclin (PGI₂) analogue, stimulates the IP receptor (PTGIR) to interact with the Gsα β/γ complex, leading to the activation of adenylate cyclase, which enzyme produces the second messenger cAMP. Elevation in cAMP triggers intracellular signalling events and regulates a wide variety of cellular activities. Thus, we evaluated the effects of Iloprost on platelet function and apoptosis and in vivo haemostasis and thrombosis, as well as the underlying mechanisms. Firstly, we showed that Iloprost concentration-dependently inhibited agonist-induced P-selectin exposure, integrin αIIbβ3 activation, platelet aggregation, ATP release, platelet spreading, and clot retraction. Moreover, Iloprost dose-dependently inhibited FeCl₃-induced mouse mesenteric arteriole t

SUBMITTER: Wang X 

PROVIDER: S-EPMC11810529 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature