Vascular endothelial growth factor in inflammatory bowel disease: A systematic review and meta-analysis.

ABSTRACT:

Aim

Vascular endothelial growth factor (VEGF) is linked to inflammation and angiogenesis, indicating a possible role in inflammatory bowel disease (IBD) and its main clinical manifestations, Crohn's disease (CD) and ulcerative colitis (UC). This systematic review and meta-analysis investigated studies assessing circulating VEGF concentrations in IBD patients and healthy controls, considering the effect of IBD type, sample type and geographical location.

Methods

A systematic search identified 18 studies (28 group comparators) investigating 1741 IBD patients and 1291 controls. Data were extracted and analysed using standardized mean differences (SMD) with 95% confidence intervals (CI).

Results

VEGF concentrations were significantly higher in IBD patients (SMD = .71, 95%

SUBMITTER: Zoroddu S 

PROVIDER: S-EPMC11810564 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature