Successful completion of large, low-cost randomized cancer trials at an academic cancer center.

ABSTRACT:

Background

Concerns about low accrual have long been a standard part of the discourse on cancer clinical trials, reaching even as far as the news media. Indeed, so many trials are closed before completing accrual that a cottage industry has recently developed creating statistical models to predict trial failure. We previously proposed four methodologic fixes for the current crisis in clinical trials: (1) dramatically reducing the number of eligibility criteria, (2) using data routinely collected in clinical practice for trial endpoints; then lowering barriers to accrual by (3) cluster randomization or (4) staged consent.

Methods

We report our practical experience of applying these fixes to randomized trials at Memorial Sloan Kettering Cancer Center.

Results

We have co

SUBMITTER: Vickers AJ 

PROVIDER: S-EPMC11810578 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature